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Home>Products>Weight Loss Steroids>Acadesine/AICAR/AICA-RIBOSIDE/AMPK/Z-RIBOSIDE polypeptide hormone CAS: 2627-69-2

Acadesine/AICAR/AICA-RIBOSIDE/AMPK/Z-RIBOSIDE polypeptide hormone CAS: 2627-69-2
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Product Details
Assay: | 98% | CAS register number: | 2627-69-2 | Molecular formula: | C9H14N4O5 |
Molecular weight: | 258.23 | Appearance: | White or white crystal | company name: | Zhuhai Shuangbojie Technology Co,.Ltd |
Payment terms: | Western Union, MoneyGram, T/T,Bitcoin | Packing: | Special disguised packaging or as your demand | Alias: | AICAR |
Product Description
Quick Detail:
Acadesine
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
CAS: 2627-69-2
EINECS: 220-097-5
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Assay: 98%
Apperance: White or off-white powder.
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases
Functions:
AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.
Biological Activity:
AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.
Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.
Specification:
Item |
Specification |
Result |
Appearance |
White powder |
Complies |
Related substance (HPLC) |
Total impurity ≤0.5% Max single impurity ≤0.1% |
0.2% 0.06% |
Odor |
Characteristic |
Complies |
Assay |
99% |
99.8% |
Sieve analysis |
100% pass 80 mesh |
Complies |
Loss on Drying Residue on Ignition |
≤1.0% ≤1.0% |
0.12% 0.09% |
Heavy Metal |
<10ppm |
Complies |
As |
<0.1ppm |
0.05ppm |
Pb |
<0.1ppm |
0.05ppm |
Cd |
<0.1ppm |
0.05ppm |
Residual Solvents |
<100ppm |
Complies |
Residual Pesticide |
Negative |
Complies |
Microbiology |
||
Total Plate Count |
<1000cfu/g |
Complies |
Yeast & Mold |
<100cfu/g |
Complies |
E.Coli |
Negative |
Complies |
Salmonella |
Negative |
Complies |
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The information you want to know
1.Payment terms:Western Union, MoneyGram, T/T,Bitcoin
2.Delivery Time:within 12hours after payment
3.Supply Ability:Plenty in Stock
4.Packing:Special disguised packaging or as your demand
5.Delivery:EMS, DHL, FedEx, Express courier.
6.available tracking numble:
EA057277290CN
EA223108200HK
EA224146399HK
367294163 TNT
EA224167283HK
EA237467692HK
EA118582471HK
About us
Zhuhaishi Shuangbojie Technology Co., Ltd, a leading manufacturer and supplier of pharmaceutical intermediates and polypeptide in China, is located in Zhuhai City Guangdong Province.Our companys various chemical raw material produtshave stable and reliable quality, it is mainly sold to pharmacy
company and health care company in abroad, like USA, Canada, UK, Brazil,Netherlands, Ireland,New Zealand, Austria,Australia and so on.
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