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Raw Steroid Powders Megestrol Acetate CAS 595-33-5 Progesterone Hormones
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Zhuhaishi Shaohui Technology Co.,ltd2020-07-10 09:46:19
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Product Details
CAS: | 595-33-5 | MF: | C24H32O4 | MW: | 384.51 |
EINECS: | 209-864-5 | Purity: | 99%min. | Properties: | Powder |
Payment: | T/T, Western Union, MoneyGram, Bitcoin | Delivery time: | Within 24 hours | Delivery Mode: | EXPRESS Door to Door |
Product Description
Raw Steroid Powders Megestrol Acetate CAS 595-33-5 Progesterone Hormones
Megestrol acetate
Product Name: Megestrol acetate
Synonyms: 17-(acetyloxy)-6-methylpregna-4,6-diene-3,20-dione;17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione;17-alpha-acetoxy-6-dehydro-6-methylprogesterone;17alpha-Acetoxy-6-dehydro-6-methylprogesterone;17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione17-acetate;5071;6-dehydro-6-methyl-17-alpha-acetoxyprogesterone;6-Dehydro-6-methyl-17alpha-acetoxyprogesterone
CAS: 595-33-5
MF: C24H32O4
MW: 384.51
EINECS: 209-864-5
Chemical Properties Crystalline Solid
Usage Progestogen;Progesterone receptor agonist
Usage Orally active progestogen; formerly used in combinations as oral contraceptive
Megestrol Acetate Description :
Megestrol acetate (INN, USAN, BAN, JAN) (abbreviated as MGA or MA, and sold mainly under the brand names Megace and Megace ES), also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects.
Though sometimes referred to simply as megestrol, it is important to clarify that megestrol acetate is not the same as megestrol, which is a closely related but different compound.
Megestrol acetate has powerful antiandrogenic and antiestrogenic effects in humans at sufficient doses, capable of decreasing circulating androgen and estrogen concentrations to castrate levels in both sexes and significantly lowering the expression of the androgen receptor (AR) and the estrogen receptor (ER) in the body.
As an example, one study in men with benign prostatic hyperplasia who were treated with 120-160 mg of megestrol acetate per day for 3 to 11 days found average decreases in AR quantity of 73% and 86% in the cytoplasm and nucleus of prostatic cells, respectively.These actions are likely the result of a strong activation of the PR, which suppresses the secretion of the gonadotropins-peptide hormones responsible for signaling the body to produce not only progesterone but also the androgens and the estrogens-from the pituitary gland as a form of negative feedback inhibition, and hence downregulates the hypothalamic-pituitary-gonadal (HPG) axis, resulting in decreased levels of the sex hormones and their associated enzymes, carriers (e.g., sex hormone-binding globulin), and receptors.It is the antiandrogenic and antiestrogenic effects of megestrol acetate mediated by suppression of the HPG axis that are believed to be largely responsible for its beneficial effects against androgen and estrogen-sensitive cancers, respectively.
Megestrol Acetate Application :
- Mainly used for short-acting oral contraceptives, also can be used for intramuscular injection of long-acting contraceptives.
- For the treatment of dysmenorrhea, amenorrhea, dysfunctional uterine bleeding, endometriosis and endometrial adenocarcinoma
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