Lidocaine CAS 137-58-6 Pharmaceutical Raw Materials Topical Anesthetic And

Quick Details:

· Lidocaine
· Alias: Xylocaine,lignocaine,,Lidocaine Base
· CAS Registry Number: 137-58-6
· Assay: 99%
· Appearance: White crystalline powder
· Packing: 1kg foil bag,25kg/drum or as your requirment
· EINECS: 205-302-8
· Molecular Formula: C14H22N2O
· Molecular weight: 234.34

. Melting point: 66-69C

. Flash point:166C

. Boiling point:350.8C at 760 mmHg

. Water solubility:practically insoluble

. Vapour Pressure:4.28E-05mmHg at 25C
· Usage: Topically used to relieve itching, burning and pain from skin inflammations, injected as a
dental anesthetic, or as a local anesthetic for minor surgery.

Product Description:
Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug.

Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations,

injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World

Health Organizations List of Essential Medicines, a list of the most important

medications needed in a basic healthcare system.

Lidocaine is the most important class-1b antiarrhythmic drug; it is used intravenously for the

treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion,

or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should

be given for this indication after defibrillation, CPR, and vasopressors have been initiated.

A routine prophylactic administration is no longer recommended for acute cardiac infarction;

the overall benefit of this measure is not convincing.

Mechanism of action: Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action.Hemodynamics:

Excessive blood levels may cause changes in cardiac output, total peripheral resistance, and mean arterial pressure. With central neural blockade these changes may be attributable to block of

autonomic fibers, a direct depressant effect of the local anesthetic agent on various components of

the cardiovascular system and/or the beta-adrenergic receptor stimulating action of epinephrine when present. The net effect is normally a modest hypotension when the recommended dosages are not exceeded.

Lidocaine Applications:
The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action

and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and

surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given

preference for subdural and epidural anesthesias; lidocaine, though, has the advantage

of a rapid onset of action.

Epinephrine vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine,

almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations

can be used e.g. for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local

freezing less painful.[2] Lidocaine drops can be used on the eyes for short ophthalmic procedures.

Relative insensitivity to lidocaine is genetic. In hypokalemic sensory overstimulation, relative

insensitivity to lidocaine has been described in people who also have attention deficit hyperactivity

disorder.In dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons

due to unexpected positions of nerves. Some people with Ehlers-Danlos syndrome are insensitive

to lidocaine.

Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in

treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge

Lidocaine patches are used to relieve the pain of post-herpetic neuralgia (PHN; the burning, stabbing pains, or aches that may last for months or years after a shingles infection). Lidocaine is in a class of medications called local anesthetics. It works by stopping nerves from sending pain signals.

Lidocaine is used on different parts of the body to cause numbness or loss of feeling for patients having certain medical procedures. It is also used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, minor cuts, or scratches.

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