Anabolic Steroid Hormones Toremifene Citrate for Cancer Patients CAS 89778-27-8

Anabolic Steroid Hormones Toremifene Citrate for Cancer Patients CAS 89778-27-8

Toremifene Citrate

Synonyms: (2-[4-((Z)-4-CHLORO-1,2-DIPHENYL-BUT-1-ENYL)-PHENOXY]-ETHYL)-DIMETHYL-AMINE;2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]-n,n-dimethyl-ethanamine;TOREMIFENE;(z)-2-(4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethanamine;2-(para-((z)-4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethylamine;2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-2-(4-(4-chloro-(z)-ethanamin;(Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxyl]-N,N-dimethylethylamine;C08166

CAS: 89778-26-7

Assay: 99%
Molecular Formula: C26H28ClNO. C6H8O7
Molecular Weight: 598.09
Melting Point: 158-164 º C
Boiling Point: 535.1 º C at 760 mmHg
Density: 1.045g/cm3
Refractive index: 1, 416-1, 418
Appearance: White or almost white powder
Usage: Originally developed to fight breast cancer, bodybuilders have used Fareston to successfully fight gynocomastia caused when testosterone converts to estrogen in the body and men grow breasts. This substance can be used for little else and other similar compounds, such as Nolvadex or Clomid, are much more effective in post-cycle-therapy.

Product Descriptions:

Toremifene Citrate is a Selective Estrogen Receptor Modulator derived from triphenylethelyne,it is used to treat breast cancer in post-menopausal women and Licensed in the United States under the brand name Fareston. It does this by exerting estrogen antagonistic effects in certain tissue,this is actually the same mechanism of action found in Nolvadex.Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body,it has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body.At the hypothalamus and pituitary, estrogen acts in cooperation with the male bodys negative feedback loop to send a signal to decrease the secretion of LH, and when LH secretion is lowered, so are natural testosterone levels.Fareston may act as an estrogen antagonist in the hypothalamus and pituitary, in order to increase testosterone production.

Toremifene Citrate improved lipid profiles, particularly as an enhancer of high density lipoprotein cholesterol. it improved low density lipoprotein cholesterol levels.Both fareston and tamoxifen selective estrogen receptor modulators and equivalent treatments for metastatic breast cancer.No significant differences were found between treatment with either tamoxifen or fareston Treatment of HR-positive patients with either tamoxifen or toremifene is appropriate.In treating idiopathic oligozoospermia, tamoxifen and fareston are roughly equally effective but raloxifene is not.The antiestrogenic effects of SERMs at the hypothalamic level result in a statistically significant increase of gonadotropin levels, which is more marked for tamoxifen and fareston compared with raloxifene.

Applications:

Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.

It has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifene pretends to be a fake Estrogen that occupies Estrogen receptors within breast tissue. With these receptors occupied by Toremifene, real Estrogen cannot perform their jobs there. Toremifene does not reduce total blood plasma levels of Estrogen. In addition to being antagonistic to Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland (this essentially ricks the hypothalamus into thinking there is little or no circulating Estrogen levels in the body, causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore these levels.

Toremifene is also agonistic to Estrogen receptors in other tissues in the body (within the liver in particular). This means that whileToremifene will act as an anti-estrogen in breast tissue and the hypothalamus, it will act as an Estrogen within the liver. This can have beneficial impacts especially during an anabolic steroid cycle, such as improving and shifting cholesterol levels into a more favorable range.

COA:

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